By Kishan J. Pandya, Julie R. Brahmer, Manuel Hidalgo
Lung melanoma is the major reason behind cancer-related deaths within the usa. Filling a niche within the literature, this source interprets fresh laboratory findings into sensible functions for the prevention and keep an eye on of lung melanoma. that includes chapters via professional researchers within the box, this reference stories present advances in imaging, drug improvement, molecular therapeutics, genetics, immunotherapy, and chemotherapy, to face on the leading edge of applied sciences for sufferer prognosis and remedy.
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Additional info for Lung Cancer: Translational and Emerging Therapies (Translational Medicine)
While there will remain a place for objective anatomical tumor response as an end point for some time in the future, the added value (or perhaps even the replacement value) of functional changes in tumor metabolism, blood flow, or other functional imaging studies requires further evaluation to standardize the description of results of trials that incorporate these measures and to determine the settings in which these modalities are most useful for drug development and patient care (37,38). Because cytostatic drugs may be erroneously defined as active on the basis of stable disease rate in an uncontrolled trial, as stable disease may be due to either inherent tumor growth kinetics or potential drug effect (35), there has been a much greater emphases on utilizing randomized controlled trials to evaluate the potential antitumor effects of these agents.
24 Gautschi et al. 90. Yeh JJ, Hsu NY, Hsu WH, et al. Comparison of chemotherapy response with P-glycoprotein, multidrug resistance-related protein-1, and lung resistance-related protein expression in untreated small cell lung cancer. Lung 2005; 183(3):177–183. 91. Ozben T. Mechanisms and strategies to overcome multiple drug resistance in cancer. FEBS Lett 2006 (Epub). 92. Belyanskaya LL, Hopkins-Donaldson S, Kurtz S, et al. Cisplatin activates Akt in small cell lung cancer cells and attenuates apoptosis by survivin upregulation.
Neuroendocrine neoplasms of the lung: a prognostic spectrum. J Clin Oncol 2006; 24(1):70–76. 88. Krug LM, Crapanzano JP, Azzoli CG, et al. Imatinib mesylate lacks activity in small cell lung carcinoma expressing c-kit protein: a phase II clinical trial. Cancer 2005; 103(10):2128–2131. 89. Boldrini L, Ursino S, Gisfredi S, et al. Expression and mutational status of c-kit in smallcell lung cancer: prognostic relevance. Clin Cancer Res 2004; 10(12 Pt 1):4101–4108. 24 Gautschi et al. 90. Yeh JJ, Hsu NY, Hsu WH, et al.